Imidacloprid is not a reproductive or developmental toxicant and is not … The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. It is frequently used in combination with other medications to treat a variety of parasites. Moxidectin is also a parasite control drug. Available for Android and iOS devices. Cats exposed to toxic chemicals may not exhibit all of the signs of poisoning. Hold applicator tube in an upright position. In case of severe flea infestation, retreatment may be necessary earlier than four weeks. Imidacloprid is also highly toxic to bees. Certain combination products should be used in cats. Every effort has been made to ensure the accuracy of the Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs.) For cats (imidacloprid moxidectin) Topical SolutionCompany: Bayer Animal Health Once-a-month topical solution for cats for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of ear mite infestations and intestinal parasite infections in cats and kittens 9 weeks of age and older and that weigh at. For this reason disposal of imidacloprid residues (e.g. The toxicity of an active ingredient must not be confused with the toxicity of finished products, in this case parasiticidal drugs or pesticides. Imidacloprid is an insecticide that was made to mimic nicotine. Copyright © 2021 Animalytix LLC. … Harmful if swallowed. If empty: Do not reuse or refill this container. Nevertheless, no this regarding guarantee is given, and any liability on its accuracy, integrity, sufficiency, actuality and opportunity is denied. Neonicotinoids bind much more strongly to insect receptors than to mammal receptors. These receptors are found in the central and peripheral nervous system of mammals, but only in the central nervous systems of insects. The EU has recently banned the use of imidacloprid and other neonicotinoids as a pesticide in certain crops because it is suspected to be associated with the Bee Colony Collapse Disorder. What should I do if my cat is showing these symptoms? Besides erroneous dosing, overdosing can occur due to, Imidacloprid is used in various products for off-animal use in livestock and poultry facilities against, Treatment consists in preventing further exposure together with. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. It happens that some users want to save money buying large tablets or spot-ons for treating smaller dogs (or even cats!) If swallowed: Call poison control center or doctor immediately for treatment advice. Any damages arising from a breach of this warranty shall be limited to direct damages and shall not include consequential commercial damages such as loss of profits or values, etc. 11556-DEU-1 EPA Reg. The product is bitter tasting and salivation may occur for a short time if the cat licks the product immediately after treatment. In cats oral intake due to intense grooming can cause hypersalivation (drooling), vomit, breathlessness. Advantage Multi® for Cats(10% imidacloprid + 1% moxidectin) is a colorless to yellow ready-to-use solution packaged in single-dose applicator tubes for topical treatment of cats. 2. 9 Citations; 638 Downloads; Abstract. Imidacloprid and Moxidectin Topical Solution n=113 Active Control n=38 * These three cats were from the same household and included one 13-yr-old cat in good health, one 15-yr-old FIV positive cat in good health, and one 15-yr-old, underweight cat in fair health. for cats (imidacloprid + moxidectin) Topical Solution Once-a-month topical solution for cats for the prevention of heartworm disease, kills adult fleas, is indicated for the treatment of flea infestations, as well as the treatment and control of ear mite infestations and intestinal parasite infections in cats and kittens 9 weeks of age and older and that weigh at least 2 lbs. Indications, Warnings and cautions for Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs. If on skin or clothing: Take off contaminated clothing. Although imidacloprid was listed as one of the world s be st-selling pesticides in 2000, th e European Union banned its use on outdoor crops entirely in 2018, after suspending its use in 2013 [3]. 5. (Doull, 1991) TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, BAYER MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY, INCLUDING ANY OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY, and no agent of Bayer is authorized to do so except in writing with a specific reference to this warranty. Liability is also denied for any possible damage or harm to persons, animals or any other goods that could follow the transmission or use of the information, data or recommendations in this site by any site visitor or third parties. 8. Symptoms appear a few hours after exposure, but depend strongly on the formulation, the dose and the kind of contact (skin, inhalation, ingestion etc). Individual sensitivities, while rare, may occur after using ANY pesticide product for pets. Remove one applicator tube from the package. 4. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Advantage is waterproof and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight. Do not contaminate water, food or feed by storage or disposal. Authors; Authors and affiliations; J. Thyssen; L. Machemer; Chapter. For the Prevention and Treatment of Flea Infestations on Cats, ● One treatment prevents further flea infestation for up to four weeks, See Below for First Aid and Precautionary Statements. Do not use combination products in young pets. The oil has a vaguely unpleasant smell but an extremely unpleasant bitter taste (though apparently not considered poisonous) for cats. Never use spot-ons for dogs in cats; never use spot-ons for large dogs in small dogs. Before using or dispensing any product, read and carefully observe the label directions. All information in this site is made available in good faith and following a reasonable effort to ensure its correctness and actuality. information published above. Combined toxicity of imidacloprid, acetochlor, and tebuconazole to zebrafish (Danio rerio): acute toxicity and hepatotoxicity assessment Environ Sci Pollut Res Int. (12%) for cats], has also been included with several of the products containing fipronil (e.g. The information in this page must not be confused with the Materials and Safety Datasheets (MSDS) officially issued by manufacturers for active ingredients and many other chemicals. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for up to four (4) weeks. Imidacloprid has a favorable toxicity profile, due to preferential activity for the nAChR subtype that occurs in insects and poor penetration of the vertebrate blood–brain barrier to reach sensitive nAChR sites in the central nervous system. Toxicology Imidacloprid, the active ingredient of CONFIDOR 200 SL and 350 SC insecticides, acts by blocking the activity of nerves in the peripheral and central nervous systems. We comply with the HONcode standard for trustworthy health information -, Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs.) Do not use on kittens under eight weeks of age. Epub 2020 Jan 13. Part the hair on the neck at the base of the skull until the skin is visible. No. Some cats may have long term disabilities after insecticide toxicity. After accidental ingestion stomach lavage as well as administration of active charcoal and laxatives is recommended. In fact, sometimes To determine the activity of fipronil and imidacloprid against larval cat fleas, immature fleas were exposed to larval-rearing medium treated with serial dilutions of each insecticide. This page contains information on Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs.) Imidacloprid was first registered in the United States (U.S.) in 1992 by Miles Inc., and was approved by the U.S. Environmental Protection Agency (EPA) in 1994 [1]. 11556-116. This chemical works by interfering with the transmission of stimuli in the nervous system of insects. Imidacloprid is very toxic to aquatic invertebrates, toxic to upland game birds, and of low toxicity to fish. 11556-DEU-1 EPA Reg. Summary of toxicity testing for health effects identified in the Health Standa rds Statute (144.0751): Even if testing for a specific health effect was not conducted for this chemical, information about that effect might be available from studies conducted for other purposes. USDA Forest Service . Avoid contact with skin. Imidacloprid is a neonicotinoid, which is a class of neuro-active insecticides modeled after nicotine.Imidacloprid is a patented chemical, Imidacloprid is manufactured by Bayer Cropscience (part of Bayer AG) and sold under trade names Kohinor, Admire, Advantage, Gaucho, Merit, Confidor, Hachikusan, Premise, Prothor, and Winner. 6. Imidacloprid: Toxicology and Metabolism. Nicotine is naturally found in many plants, including tobacco, and is toxic to insects. Imidacloprid Side Effects, Adverse Drug Reactions (ADRs) and Warnings. Never place unused product down any indoor or outdoor drain. If you intend to use a veterinary drug containing this active ingredient you must carefully read and follow the safety instructions in the product label. Do not induce vomiting unless told to do so by the poison control center or doctor. Imidacloprid is moderately toxic to fish and highly toxic to aquatic invertebrates. ). Do not get in eyes or on clothing. It affects the nervous system of parasites, leading to their death, but is considered non-toxic to mammals. The compound is also used for flea treatment on cats, whose livers have only limited detoxification ability compared to dogs and humans. It has been used in products sold in the United States since 1994. Correct use on dogs and cats is unlikely to result in any significant environmental pollution. Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs.). Do not contaminate feed or food. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents of the tube directly on the skin. Imidacloprid is used on and off label and is applied topically to the skin to treat flea infestations. Code 00837869-032699 - Four 0.014 fl oz (0.4 mL) Tubes, Code 01791668-053699 - Six 0.014 fl oz (0.4 mL) Tubes, EPA Est. Select one or more newsletters to continue. This makes them relatively safe for domestic animals and humans. Do not use on other animals. and cats are products used to control rodents; baits applied for slug and snail control; herbicides applied to lawns; and insecticides used in flea collars and spot-on products. Regulations for product use are established by country. Have the product container or label with you when calling a poison control center or doctor, or going for treatment. Advantage 18 Topical Solution - Purple/18 For Cats and Kittens 8 Weeks and Older and Over 9 lbs. 1 Imidacloprid spot on products are labeled to kill adult fleas and their larvae in dogs and cats. Submitted to: Dr. Harold Thistle . The successive feeding activity of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis (FAD). Imidacloprid is toxic to terrestrial birds but not to other ones (e.g. 2,19 In mice, LD 50 values were estimated at 130 mg/kg for males and 170 mg/kg for females. Signs of toxicity would be expected to be similar to nicotinic signs and symptoms, including lethargy, muscle fasiculations, tremors, and muscle weakness. Imidacloprid: Human Health and . HAZARDS TO HUMANS: Causes eye irritation. ), Direction and dosage information for Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs. Pyrethrin/pyrethroid toxicity is fatal for cats if not treated immediately. In severe cases, cats that do not receive treatment quickly die in just a few hours after exposure. Ecological Risk Assessment . Persistence is longer in soils with an organic cover. Health Canada has stated that the chemical's toxicity … The primary symptoms of intoxication with imidacloprid and other neonicotinoids resemble nicotine intoxications. The outlook for cats diagnosed with insecticide toxicity depends on the severity of symptoms and internal damage. Nicotinic activity is only evident in mammals at high doses, with effects on the liver at lower doses. If in eyes: Hold eye open and rinse slowly and gently with water for 15 - 20 minutes. Due to the large safety margin of imidacloprid, signs are rarely seen. Call a poison control center or doctor for treatment advice. Keep out of reach of children. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. The chemical name of imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidini… for veterinary use. Treatment administered to the mother will protect the litter. Signs of toxicity. … When it comes to insecticide … Advantage kills fleas on cats within 12 hours. The half-life of imidacloprid in soil is quite long, 48 to 190 days. If partly filled: Call your local solid waste agency or 1-800-422-9874 for disposal instructions. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. Code 00837877-032799 - Four 0.027 fl oz (0.8 mL) Tubes, Code 01791692-053799 - Six 0.027 fl oz (0.8 mL) Tubes, EPA Est. Once-A-Month Topical Flea Treatment for Cats and Kittens 8 Weeks and Older. Imidacloprid is used to control sucking insects, termites, some soil insects, and fleas on pets. Flumethrin formulations come as a spray or dip and as a one-percent solution pour-on treatment. WHO Acute Hazard classification of pesticides: Class II, moderately hazardous. Imidacloprid - 4 . To Physician: Treat the patient symptomatically. 1. This allows a rather long residual effect against. However, many cats recover if they are taken to their veterinarian promptly and treated. In cats oral intake due to intense grooming can cause hypersalivation (drooling), vomit, breathlessness. Do not use on unweaned kittens or puppies. Einige Experten nehmen an, dass Imidacloprid derzeit das weltweit meistverwendete Insektizid ist. Frontline Plus for dogs or cats and Startgard Plus for puppies or kittens). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Finished products contain one or more active ingredients, but also other ingredients that can be relevant from the safety point of view. 1 The manufacturer states that these products should be used with caution in debilitated, aged, pregnant, or nursing animals, and kittens or puppies less than 4 months of age. Treatment at the base of the skull will minimize the opportunity for the cat to lick the product. Do not get this product in your pet’s eyes or mouth. The originating document has been archived. 180 Canfield St. Morgantown, WV 26505 . For consumer questions call 1-800-255-6826. For external use only. WHO Acute Hazard classification of pesticides. Corrected FINAL REPORT . USDA Forest Service Contract: AG-3187-C-12-0009. 1 Imidacloprid … Pull cap off tube. After flea control is attained, return to monthly retreatment schedule. 19,20 See the text boxes on Toxicity Classification and LD 50 /LC 50. ducks). Bayer HealthCare LLC, Animal Health Division warrants that this material conforms to the chemical description on the label. Toxicity of inerts to cats: An uniden-tified inert ingredient in Advantage, an imidacloprid flea insecticide applied as drops on the back of a pet’s neck, can be toxic to kittens when applied above the label rate. treated once at up to 20x the therapeutic dose (200 mg/kg) showed no adverse effects. Wash hands thoroughly with soap and warm water after handling. In case of dermal exposure rinse the skin with abundant water and soft detergents. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The treatment schedule should be based on the local epidemiological situation. SERA Internal … There is a certain risk of groundwater contamination in porous soils. Monthly treatments are required for optimal control and prevention of fleas. Larval flea stages in the pet’s surroundings are killed following contact with an Advantage treated pet. Imidacloprid toxicity may occur through incorrect dosing, or from accidental ingestion when the animal licks the site of application. 7. It is also toxic to upland game birds, is generally persistent in soils and can leach to groundwater. Have person sip a glass of water if able to swallow. For medical emergencies call 1-800-422-9874. When applied topically to animals it quickly dissolves in the lipids of the hair-coat and the body surface. Advantage 18 (imidacloprid) Topical Solution for Cats and Kittens (8 Weeks and Older, Over 9 lbs.) If you suspect that your cat is having a severe reaction to a pyrethrin or pyrethroid, please bring your cat to your regular or emergency veterinarian immediately. 11556-118, Manufactured For Bayer HealthCare LLC, Animal Health Division, Shawnee Mission, Kansas 66201 USA, Bayer, the Bayer Cross and Advantage are registered trademarks of Bayer, Advantage is protected by the following U.S. patents: 6,232,328 and 6,001,858. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. Imidacloprid is neither carcinogenic in laboratory animals nor mutagenic in standard laboratory assays. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Do not give anything by mouth to an unconscious person. Imidacloprid belongs to the group of chloronicotinyl compounds and has excellent insecticidal properties, coupled with low mammalian toxicity. Call poison control center or doctor for treatment advice. It has moderate acute mammalian toxicity following oral administration, but low toxicity if inhaled or applied to the skin. Imidacloprid ist ein systemisches Insektizid aus der Gruppe der Neonicotinoide. Be aware that the safety instructions for the same veterinary medicine may vary from country to country. Die Substanz wurde 1985 in den Labors der Bayer AG erstmals synthetisiert. Email: hthistle@fs.fed.us . MSDSs target safety during manufacturing, transport, storage and handling of such materials. in empty containers) in watercourses must be absolutely avoided. Flumethrin is a fat-soluble pyrethroid insecticide and acaricide used in the control of ectoparasites on farmed livestock like cattle, sheep, goats and horses, and domestic animals such as dogs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing animals. (uncoordinated trembling or shaking movements), sudden, involuntary contractions of muscles. Toxicological information on this class of substances is nearly nonexistent in open literature. In addition, it is marketed for the diagnosis and control of varroatosis in bee hives. Advantage 9 Topical Solution - Orange/9 For Cats and Kittens 8 Weeks and Older and 9 lbs. It specifically causes a blockage in a neuronal pathway (nicotinergic) that occurs more in insects than … Transient skin reactions and eye irritation have been also reported. Integrated Pest Management – Although sometimes using pesticides is necessary, an Integrated Pest Manage-ment (IPM) approach can minimize pesticide use and greatly reduce the risk of accidental pet poisoning. This is why you must act with great stealth and under cover of catnip. Treatment of cats with Advantage rapidly kills fleas and may reduce the incidence of this condition. Do not retreat more often than once every 7 days. Discard empty tube as described in Storage and Disposal. However a certain amount can be ingested through licking and grooming. Imidacloprid is one of the most popular and widespread insecticides in the U.S. Imidacloprid is toxic to birds, honey bees, mammals and earthworms. The information provided typically includes the following: Valentina M. Merola, Paul A. Eubig, Toxicology of Avermectins and Milbemycins (Macrocyclic Lactones) and the Role of P-Glycoprotein in Dogs and Cats, Veterinary Clinics of North America: Small Animal Practice, 10.1016/j.cvsm.2018.07.002, 48, 6, (991-1012), (2018). Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. If signs persist, or become more severe, consult a veterinarian immediately. Imidacloprid is moderately soluble in water and has a moderate affinity for organic materials. It is primarily used to prevent heartworm infection. Once a cat has tasted imidacloprid it will never forget the memory of the smell. Turn the cap around and place other end of cap back on tube. Imidacloprid is quite lipophilic. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. No. Preexisting pupae in the environment may continue to emerge for six (6) weeks or longer depending upon the climatic conditions. Safe for use with pregnant or nursing dogs and cats.

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