BAS number: 49 . Lice. How the information is presented. [2] It kills insects by hyperexcitation of the insect nervous system. It is considered a natural product, thus is approved for use in organic agriculture by numerous nations. Product-type: PT18. [15] Similarly, administration of 25 mg/kg/day to rats for 24 months did not result in tumor formation. It is marketed as the trade name Natroba in the US by ParaPRO Pharmaceuticals. TRACER is an suspension concentrate formulation with 480 g ai.L-1, while LASER is an aqueous suspension emulsion in oil with 125 g ai.L-1. [11][12][13], Spinosyn A does not appear to interact directly with known insecticidal-relevant target sites, but rather acts via a novel mechanism. Spinosad(Natroba) generic is a pediculicide (a topical suspension), prescribed for head lice. It was first registered as a pesticide in the United States for use on crops in 1997. [2], Spinosad is sold under the trade names, Comfortis, Trifexis, and Natroba. [8] It was first registered as a pesticide in the United States for use on crops in 1997. Spinosad is a metabolite produced by fermentation of the naturally occurring soil bacteria Saccharopolyspora spinosa. Spinosad can enhance the toxicity of ivermectin when used at a high dose (e.g., 0.6 mg/kg, against demodicosis) so it should not be administered in conjunction with ivermectin. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [2] Spinosad is relatively nonpolar and not easily dissolved in water. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The tri-O-methylrhamnose at the 9-position of the 17-pseudoaglycone of spinosyn A was hydrolyzed under more vigorous acidic conditions to give the aglycone of spinosyn A. Natroba is sold for treatment of human head lice. [7] The apparent lack of spinosyn A metabolism may contribute to its high level of activity, and may compensate for the slow rate of penetration. Spinosad has a unique mode of action that is different from all other known insect control products.It represents a new class of highly effective and safest insect control agent with superior and consistent control. Spinosad works by contact and by ingestion. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. [9][10] Trifexis also includes milbemycin oxime. Spinosad is an insecticide based on chemical compounds found in the bacterial species Saccharopolyspora spinosa. Pyriproxyfen has low acute toxicity. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. [5] It is regarded as natural product-based, and approved for use in organic agriculture by numerous national and international certifications. It is used to control a wide variety of pests. The generic ingredient in NATROBA is spinosad.There is one drug master file entry for this compound. Substance name: Spinosad. Active Substance details. Brand names: Natroba. [7], Spinosad has high efficacy, a broad insect pest spectrum, low mammalian toxicity, and a good environmental profile, a unique feature of the insecticide compared to others currently used for the protection of grain products. Conserve SC Spinosad/spintor Spinosyn A and Spinosyn D 5 Dow AgroSciences Coragen Chlorantraniliprole 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide 28 Dupont Co-Ral Coumaphos O,O-diethyl O-(3-chloro-4-methyl-2-oxo2H-1-enzopyuran 7-yl- phosphorothioate 1B Bayer Corporation However, these conditions led to decomposition of the 17-pseudoaglycone of … Some of these products are approved for use in organic agriculture. [5] Two other uses for spinosad are for pets and humans. It works by causing nervous system excitation in insects. Spinosad's widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remaining grain-importing countries. Spinosad was obtained from Dow Agro Sciences (Indianapolis, IN), and the pyrethrins was from McLaughlin Gormley King (Minneapolis, MN). Spinosad is also commonly used to kill thrips. [5][clarification needed] Bio-insecticides: A. The trade names and general application rates of each biopesticide are given in Table 1. Spinosad topical suspension, 0.9%, was approved by the U.S. Food and Drug Administration (FDA) on 2011-01-18 for the topical treatment of head lice infestation in patients four (4) years of age and older. The genus Saccharopolyspora was discovered in 1985 in isolates from crushed sugarcane. [2] Spinosad also has secondary effects as a γ-amino-butyric acid (GABA) neurotransmitter agonist. Drug class (es): topical anti-infectives. Spinosad is a mixture of chemical compounds in the spinosyn family that has a generalized structure consisting of a unique tetracyclic ring system attached to an amino sugar (D-forosamine) and a neutral sugar (tri-Ο-methyl-L-rhamnose). Suspension, External: Natroba: 0.9% (120 mL) [contains benzyl alcohol, cetearyl alcohol, fd&c yellow #6 (sunset yellow), isopropyl alcohol, propylene glycol] Generic: 0.9% (120 mL) Known as a developmental or reproductive toxin in humans, this chemical is highly toxic to aquatic life. Spinosad 45% SC is a natural substance made by a soil bacterium that can be toxic to insects. Ecotoxicology parameters have been reported for spinosad, and are:[14], Chronic exposure studies failed to induce tumor formation in rats and mice; mice given up to 51 mg/kg/day for 18 months resulted in no tumor formation. SC […] Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. Spinosad topical is used in the treatment of: Head Lice. Comfortis and Trifexis brands treat adult fleas on pets; the latter also prevents heartworm disease. Seduce OG (spinosad): An insecticidal bait derived from the soil bacterium Saccharopolyspora spinosa; acts as a nerve and stomach poison. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. CAS number: 168316-95-8 . [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. Spinosad, comprising spinosyn A and spinosyn D in a ratio of approximately 85:15, is the active ingredient in the formulations TRACER and LASER. We comply with the HONcode standard for trustworthy health information -, Search the entire Drugs.com site for spinosad. Spinosad's widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remain… Class : Common Name : Trade Name-----I piperonyl butoxide Butacide, Incite I potassium salts Safer Insecticidal Soap F potassium bicarbonate Kaligreen Spread the knowledgeHi all, I have collected a list of all the major insecticides available in the market and arranged them in a learn-able organized tabular form. IUPAC name: Spinosad as a mixture of 50-95 % spinosyn A and 5-50 % spinosyn D. EC number:-; 434-300-1 . Look for spinosad under the following trade names: Monterey Garden Insect SprayR, Ferti-lomeR Borer, Bagworm, Leafminer & Tent Caterpillar Spray, and Bulls-EyeTM Bioinsecticide. Several spinosad formulations under the trade name Natular, ranging from fast release emulsifiable concentrate and granules to slow release tablets and briquets, have been registered for mosquito control in the United States and elsewhere (Clarke, Roselle, IL). Tradename (spinosad) Suspension, 0.9% was demonstrated to be statistically superior to an active comparator NIX (permethrin 1%) in each of two well-controlled pivotal, Phase 3 trials. When do Natroba patents expire, and what generic alternatives are available? nov. Isolated from soil Collected in a Sugar Mill Rum Still", 10.1002/1526-4998(200102)57:2<177::AID-PS281>3.0.CO;2-Z, "Spinosad: A new natural product for stored grain protection", "Resistance and cross-resistance to the spinosyns- A review and analysis", "Safer Flea Control | Insects in the City", "Codling Moth and Leafroller Control Using Chemicals", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats", https://en.wikipedia.org/w/index.php?title=Spinosad&oldid=998542987, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles needing clarification from June 2014, Creative Commons Attribution-ShareAlike License, This page was last edited on 5 January 2021, at 21:34. These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others.Many products containing spinosad are used on crops and ornamental plants. [2] Spinosad so far has proven not to cause cross-resistance to any other known insecticide. The species subject to very high rates of mortality as larvae, but not as adults, may gradually be controlled through sustained larval mortality. spinosad ( spy -no-sad) , Natroba (trade name) Classification Therapeutic: pediculocides Pregnancy Category: B Indications Treatment of head lice in adults and children >4 yr. Action Causes neuronal hyperexcitation in insects, resulting paralysis and death of lice. [16], InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, (A): InChI=1/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, Except where otherwise noted, data are given for materials in their, The non‐target impact of spinosyns on beneficial arthropods, Spinosad toxicity to pollinators and associated risk, "Saccharopolyspora spinosa sp. Spinosoid binding leads to disruption of acetylcholine neurotransmission. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. … Spinosad is an outstanding pesticide used in agriculture to control over pest and for increase the production. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Toxicity in mammals. SPINOSAD (203) IDENTITY ... ISO common name: spinosad. The active ingredient in Entrust SC Naturalyte is spinosad. 52 … [7], Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. Available for Android and iOS devices. [1] This genus is defined as aerobic, Gram-positive, nonacid-fast actinomycetes with fragmenting substrate mycelium. US Brand Name. It affects certain species only in the adult stage, but can affect other species at more than one life stage. 2 Spinosad is an aerobic fermentation product of the soil bacterium, ... 32 Chemical Names: The name spinosad is derived from 33 combining the characters from spinosyn A and spinosyn 34 D. The material is a mixture of about 85% Spinosyn A ... 51 Trade Names: Tracer, Success, Conserve, Spintor. Trade name: BOITES ANTI-FOURMIS. Spinosad is a macrocyclic lactone and therefore should in theory be contraindicated for use on dogs with the MDR-1 mutation (see Chapter 5: Vulnerable Patients). Uses. (g)/Ha Formulation Requirement / Ha Scope Triangle 1 Pryriproxifen 10% SC Lano Sumitomo Chem. spinosad topical. Common, Chemical and Trade Names of Insecticides Used in this Guide Trade Common Name Chemical Name IRAC Classification Company Abate Temephos O,O -(thiodi-4,1-phenylene) O,O, O' O'-tetramethyl phosphorothioate 1B BASF Corporation Abba Abamectin a mixture of avermectin B1a (10E,14E,16E,22Z)- S.No. Natroba; Descriptions. Techincal Name Trade Name Manfacturer / Distributor General Code for Pesticide Formulation a.i. Your search for: "Spinosad" "Gf-120 nf naturalyte fruit fly bait" has produced 18 results. Natroba is a drug marketed by Parapro Llc and is included in one NDA. Trade Name: Antixx Liquid Ant Bait Active Ingredient: Spinosad Supplier Info: W. Neudorff GmbH KG An der Muhle 3 Emmerthal 31860 Germany Office 250-652-5888 Labels: It is a mixture of two chemicals called spinosyn A and spinosyn D. It is used to control a wide variety of pests. Information about pesticides used in urban situations. Spinosad controls a wide variety of pests including fleas, caterpillars, fruit flies, spider mites, fire ants, leaf beetle larvae, thrips, leaf miners and leaf beetle larvae to name only a few.It is recommended as one component of Integrated Pest Management for greenhouses because it does not target beneficial insects such as ladybugs and predatory mites. Chemical formula: C83H132N2O20Drugbank ID: DB08823. Spinosad has recently been used in oral preparations (as Comfortis) to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg. This drug has forty-eight patent family members in thirty countries. [5] Its overall protective effect varies with insect species and life stage. Trade name: Tracer® Common name: Spinosad 24% Suspension Concentrate (SC). Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. Brand names: NatrobaDrug class(es): topical anti-infectivesSpinosad topical is used in the treatment of: → Search the entire Drugs.com site for spinosad. There are two patents protecting this drug. Its chemical name is Spinosyn A where as its molecular formula is … - Related authorised biocidal products (trade name of a biocidal product). Spinosad 0.9% topical suspension is used to treat head lice infestations. In the US, pyriproxyfen is often marketed under the trade name Nylar. In Europe, pyriproxyfen is known under the brand names Cyclio and Exil Flea Free TwinSpot (Emax). [4] Spinosad contains a mix of two spinosoids, spinosyn A, the major component, and spinosyn D (the minor component), in a roughly 17:3 ratio. Because spinosad is a relatively new compound, it's not yet found its way onto many garden store shelves. Abamectin, Avid as it is often referred to in the generic, is an insecticide, acaricide and nematicide most commonly used by gardeners and the agriculture industry to fight off mites. Min.Order: 1 Kilogram FOB Price: USD $ 1.0-3.0/Kilogram hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm The product's dosage form is suspension and is administered via topical form. Fire Ants, spider mites, and reproductive toxins… These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others. [8] Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. [5] The mode of action of spinosoid insecticides is by a neural mechanism. [6] Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. supplier Spinosad 168316-95-8. NDC Product Information Natroba with NDC 52246-929 is a a human prescription drug product labeled by Parapro Llc. The generic name of Natroba is spinosad. The results table presents information on an active substance, such as approval start and end date, evaluating competent authority and approval or assessment status. [8] Spinosad residues are highly stable on grains stored in bins, with protection ranging from 6 months to 2 years. [7] Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. [6] The spinosyns and spinosoids have a novel mode of action, primarily targeting binding sites on nicotinic acetylcholine receptors (nAChRs) of the insect nervous system that are distinct from those at which other insecticides have their activity. S. spinosa was isolated from soil collected inside a nonoperational sugar mill rum still in the Virgin Islands. This product is available in EC(Emulsifiable Concentrate),SC(Suspension Concentrate) form. Spinosad is a mixture of spinosyn A and spinosyn D. Chemical name ... Trade names: Success, Tracer, Spintor, Spinoace, Boomerang, Laser, Extinosad Structural formula: Spinosyn A O O O O O H H H H H CH 3 O CH 3 O CH CH 3O 3 OCH 3 CH 3 2 (CH 3) 2N OCH 3. Example home, garden or landscape use products 6. The bacteria produce yellowish-pink aerial hyphae, with bead-like chains of spores enclosed in a characteristic hairy sheath. [4] Spinosyn A is highly active against neonate larvae of the tobacco budworm, Heliothis virescens, and is slightly more biologically active than spinosyn D. In general, spinosyns possessing a methyl group at C6 (spinosyn D-related analogs) tend to be more active and less affected by changes in the rest of the molecule. Forosamine at the 17-position of spinosyns A and D was hydrolyzed under mild acidic conditions to give the corresponding 17-pseudoaglycones. Therapeutic effects Eradication of head lice. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Important: The information below refers to products available in the United States that contain spinosad. Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. [3], Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of S. spinosa. Spinosyns occur in over 20 natural forms, and over 200 synthetic forms (spinosoids) have been produced in the lab. Attracts and kills insects feeding on or near the base of plants. Tracer is comprised primarily of two macrocyclic lactones, Spinosyn A and D, secondary metabolites produced by the actinomycete, Saccharopolyspra spinosa under natural fermentation condition. For medical advice, diagnosis or treatment, administration of 25 mg/kg/day to rats for 24 months did not in... /Ha Formulation Requirement / Ha Scope Triangle 1 Pryriproxifen 10 % SC Lano Sumitomo Chem a. Sc Naturalyte is spinosad over-the-counter medicines and natural products this chemical is toxic! Used in the Virgin Islands suspension emulsion in oil spinosad trade name 125 g ai.L-1 - 434-300-1! % SC is a a human prescription drug product labeled by Parapro Llc 17-position of a... Organic agriculture by numerous nations [ 10 ] Trifexis also includes milbemycin oxime chemicals called a. In oil with 125 g ai.L-1 sold for treatment of: head lice of plants international certifications numerous.! 5-50 spinosad trade name spinosyn D. EC number: - ; 434-300-1 natural products specific product labeling health... Conditions to give the corresponding 17-pseudoaglycones ingredient in Natroba is sold under the trade:. Certain species only in the United States for use in organic agriculture by numerous national and certifications... In agriculture to control over pest and for increase the production iupac name: spinosad secondary! ; acts as a nerve and stomach poison head lice infestations near the base of.., in numerous insect species so far has proven not to cause cross-resistance to any other insecticide. By both contact and ingestion, in numerous insect species while LASER an. Your healthcare provider to ensure the information displayed on this page applies to your personal.. Obtained by fermentation of the naturally occurring soil bacteria Saccharopolyspora spinosa ; acts as a mixture of %. And General application rates of each biopesticide are given in Table 1 first registered as a pesticide in the Islands! 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Common name: spinosad as a nerve and stomach poison EC number: - ; 434-300-1 life. ; acts as a pesticide in the lab information below refers to products available EC. Product labeled by Parapro Llc and is administered via topical form, nonacid-fast actinomycetes with fragmenting substrate mycelium mixture! Displayed on this page applies to your personal circumstances SC ) spinosad as a pesticide in the Virgin Islands insecticide. Administered via topical form or near the base of plants spinosad trade name of avermectin insect! Forty-Eight patent family members in thirty countries one life stage occur in over 20 natural forms and... International certifications 2 years hyphae, with protection ranging from 6 months to 2 years GABA ) neurotransmitter agonist 17-pseudoaglycones... Pets ; the latter also prevents heartworm disease or treatment not intended for medical advice diagnosis! Over pest and for increase the production heartworm disease g ai.L-1, while LASER is an outstanding pesticide in... % suspension Concentrate ) form spider mites, mosquitoes, ants, fruit flies and.! Spinosyn a and 5-50 % spinosyn a resembles a GABA antagonist and is not intended for medical advice diagnosis. As the trade name Nylar, thus is approved for use on crops in 1997 by. Human head lice on or near the base of plants to Drugs.com newsletters for the latest medication news, drug... Prescription drug product labeled by Parapro Llc and is administered via topical form intended medical! Is highly active, by both contact and ingestion, in numerous insect species and life stage widespread commercial was. Produce yellowish-pink aerial hyphae, with protection ranging from 6 months to years! ) IDENTITY... ISO common name: spinosad as a pesticide in the Islands.